GHK-Cu
low riskAlso: Copper peptide · Glycyl-L-histidyl-L-lysine copper
GHK-Cu is a naturally occurring copper complex with strong evidence for skin rejuvenation, wound healing, and gene expression modulation. One of few cosmetic peptides on the FDA 503A list. Influences expression of ~4,000 genes per genomic studies.
Reported Benefits
Skin rejuvenation
Human clinical trials show increased skin thickness, collagen density, reduced wrinkle depth.
Wound healing
Accelerates wound closure and improves tensile strength in human and animal studies.
Hair growth
Small studies show increased follicle size and hair growth rate.
Mechanism of Action
Modulates ~4,000 genes; upregulates collagen, elastin, VEGF; downregulates inflammatory cytokines; acts as superoxide dismutase mimic.
Key Clinical Studies
Leyden et al. (2009)
RCT (double-blind) · n=67
Improved skin laxity, density, and fine lines vs. placebo at 12 weeks
Broad Gene Modulation
Loren Pickart’s research showed GHK-Cu influences expression of over 4,000 human genes — tilting expression toward tissue repair, antioxidant defense, and reduced inflammation.
503A Status
One of few cosmetic peptides with a clear legal compounding path in the US. Topical formulations are widely available through licensed compounding pharmacies.
Regulatory Status
503A ListedListed on 503A bulk substances list for topical compounding
Safety Profile
Side Effects
- •Mild irritation (topical)
- •Blue-green discoloration (high topical concentrations)
Contraindications
- •Wilson's disease (copper metabolism disorder)
Primary Uses
Weekly Briefing
Regulatory updates + new study breakdowns.
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