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Evidence-Based Peptide Intelligence

Peptide intelligence without the bullsh*t.

94 peptides. Honest evidence ratings. Regulatory status. No vendor relationships. No hype.

94
Peptides Profiled
16
FDA-Approved
8
Conditions Covered
Zero
Vendor Relationships

Strongest Evidence

FDA-approved or strong clinical evidence

View all 94 →

Semaglutide

therapeutic

Semaglutide is an FDA-approved GLP-1 receptor agonist with the strongest clinical evidence of any peptide on the market. STEP trials: 15–17% body weight reduction. SELECT trial: 20% cardiovascular risk reduction in non-diabetic overweight patients. The defining weight-loss drug of the 2020s.

Type 2 diabetesObesity/weight lossCardiovascular risk reduction
Strong Evidence FDA Approved

Tirzepatide

therapeutic

Tirzepatide is a dual GLP-1/GIP receptor agonist consistently outperforming semaglutide in trials. SURMOUNT-1: 20.9% weight loss. FDA approved as Mounjaro (T2D) and Zepbound (obesity). Current efficacy benchmark for GLP-1 class therapies.

Obesity/weight lossType 2 diabetesCardiovascular risk
Strong Evidence FDA Approved

BPC-157

therapeutic

BPC-157 is a pentadecapeptide derived from a gastric juice protective protein. Over 100 animal studies demonstrate broad tissue-protective and healing effects. No completed human RCTs, but Phase II IBD trials have been conducted. One of the most-studied research peptides.

Gut healingTendon repairNeuroprotection
Moderate Evidence Research Only

PT-141

therapeutic

Bremelanotide (PT-141) is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women. Acts centrally on brain melanocortin pathways governing sexual motivation — unlike PDE5 inhibitors which work peripherally. Also used off-label for male ED.

Female sexual dysfunction (HSDD)Male erectile dysfunction (off-label)
Strong Evidence FDA Approved

Sermorelin

therapeutic

Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) approved for pediatric growth hormone deficiency. It stimulates pituitary GH release through the body's own feedback mechanisms, making it a physiologically regulated alternative to exogenous HGH.

Growth hormone deficiency (pediatric)Adult GH optimizationAnti-aging protocols
Moderate Evidence FDA Approved

Thymosin Alpha-1

therapeutic

Thymosin Alpha-1 is one of the most clinically validated immune peptides. Approved as Zadaxin in 35+ countries for hepatitis B/C and cancer immunotherapy. Meta-analysis of 7 RCTs shows significant mortality reduction in sepsis. Gold standard immune peptide.

Immune enhancementHepatitis B treatmentSepsis adjunct
Strong Evidence FDA Approved

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