Evidence-Based Peptide Intelligence
Peptide intelligence without
the bullsh*t.
94 peptides. Honest evidence ratings. Regulatory status. No vendor relationships. No hype.
Strongest Evidence
FDA-approved or strong clinical evidence
Semaglutide
therapeuticSemaglutide is an FDA-approved GLP-1 receptor agonist with the strongest clinical evidence of any peptide on the market. STEP trials: 15–17% body weight reduction. SELECT trial: 20% cardiovascular risk reduction in non-diabetic overweight patients. The defining weight-loss drug of the 2020s.
Tirzepatide
therapeuticTirzepatide is a dual GLP-1/GIP receptor agonist consistently outperforming semaglutide in trials. SURMOUNT-1: 20.9% weight loss. FDA approved as Mounjaro (T2D) and Zepbound (obesity). Current efficacy benchmark for GLP-1 class therapies.
BPC-157
therapeuticBPC-157 is a pentadecapeptide derived from a gastric juice protective protein. Over 100 animal studies demonstrate broad tissue-protective and healing effects. No completed human RCTs, but Phase II IBD trials have been conducted. One of the most-studied research peptides.
PT-141
therapeuticBremelanotide (PT-141) is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women. Acts centrally on brain melanocortin pathways governing sexual motivation — unlike PDE5 inhibitors which work peripherally. Also used off-label for male ED.
Sermorelin
therapeuticSermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) approved for pediatric growth hormone deficiency. It stimulates pituitary GH release through the body's own feedback mechanisms, making it a physiologically regulated alternative to exogenous HGH.
Thymosin Alpha-1
therapeuticThymosin Alpha-1 is one of the most clinically validated immune peptides. Approved as Zadaxin in 35+ countries for hepatitis B/C and cancer immunotherapy. Meta-analysis of 7 RCTs shows significant mortality reduction in sepsis. Gold standard immune peptide.
Browse by Condition
Relevant peptides organized by clinical indication
Latest Intel
Regulatory updates, research breakdowns, market intelligence
CJC-1295 with DAC vs. Without: Understanding the Half-Life Tradeoff
The DAC modification extends half-life from minutes to days. Cover the pharmacokinetic tradeoff, blunted pulsatile GH re...
3 min · 2026-07-09
ClinicalPeptide Stability and Storage: The Pharmacist's Perspective on What Actually Matters
Practical guide: lyophilized vs. reconstituted stability, temperature sensitivity by peptide class, light degradation, b...
3 min · 2026-07-07
ResearchSemax and the Russian Bioregulator Tradition: What Western Practitioners Need to Know
Semax is approved in Russia for stroke and cognitive impairment. Review the ACTH fragment mechanism, the Russian RCT dat...
3 min · 2026-07-04
Find a practitioner. Or become one.
Ercle's provider directory connects patients who've done their research with practitioners who prescribe evidence-based peptide protocols.
Find a Provider
Browse vetted practitioners who prescribe peptide protocols. Filter by specialty, location, and telehealth availability.
Browse directory →List Your Practice
Get in front of high-intent patients who've already researched their protocol. Listings from free — featured from $99/mo.
Get listed →Weekly Intelligence
The Peptide Evidence Briefing
Regulatory updates, new study breakdowns, and evidence reviews — delivered every week. Free.
No spam. Unsubscribe anytime. No vendor relationships.
Evidence-Rated
Every entry rated Strong, Moderate, Preliminary, or Insufficient. No grade inflation.
No Vendor Bias
No compensation from peptide vendors, compounding pharmacies, or supplement companies. Ever.
Regulatory Honest
We state what's approved, what's compoundable, and what's research-only. No euphemisms.