Vesugen

unknown risk

Also: Lys-Glu-Asp · KED tripeptide

Preliminary Research Only

Vesugen is a synthetic tripeptide (Lys-Glu-Asp) from the Khavinson series specifically targeted at vascular tissue. It is claimed to regulate endothelial gene expression and reduce age-related vascular deterioration.

Molecular Weight

421.4 g/mol

Formula

C16H27N5O8

Common Dosing

1-2 mg/day for 10-day courses

Reported Benefits

Vascular Aging

Preliminary 8 studies

Russian studies show improved vascular elasticity markers in aged subjects.

Endothelial Function

Preliminary 5 studies

Proposed modulation of endothelial gene expression.

Mechanism of Action

Vesugen is proposed to penetrate endothelial cell nuclei and modulate expression of genes involved in vascular homeostasis, including those regulating vessel elasticity, nitric oxide production, and inflammatory cytokine expression.

Key Clinical Studies

Khavinson VKh (2011)

pilot · Aged subjects

Improved vascular biomarkers with vesugen courses

Overview

Vesugen targets one of the most clinically significant aspects of aging: vascular deterioration. Age-related vascular stiffness, endothelial dysfunction, and chronic low-grade vascular inflammation contribute to hypertension, atherosclerosis, and cardiovascular mortality. A peptide that genuinely modulates vascular aging would be clinically valuable.

Evidence Standard

The evidence for vesugen mirrors other Khavinson bioregulators: pilot studies from a single Russian institute suggesting benefit, with no independent large-scale validation. The vascular endpoint claims require prospective trials with objective vascular measures (pulse wave velocity, flow-mediated dilation) conducted independently.

Vascular Peptide Field Context

The broader vascular peptide space includes better-characterized compounds like angiotensin 1-7 (alamandine axis), natriuretic peptides, and adrenomedullin — all with stronger independent evidence bases.

Regulatory Status

Research Only

Russian bioregulator; no FDA/EMA approval

Safety Profile

Side Effects

•Injection site reactions

Contraindications

•Cardiovascular disease (consult physician)

Drug Interactions

•Antihypertensives

Primary Uses

Cardiovascular healthVascular anti-agingEndothelial functionHypertension

Related Peptides

cortagen ghk-cu angiotensin-1-7

Weekly Briefing

Regulatory updates + new study breakdowns.

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Disclaimer: This information is for educational and research purposes only. Not medical advice. Consult a qualified healthcare provider before using any compound.