Melanotan II

high risk

Also: MT-2 · PT-14 predecessor · Tanning peptide

Preliminary Research Only

Melanotan II is a non-selective melanocortin agonist (MC1R, MC3R, MC4R) developed before PT-141 was derived from it. Causes melanogenesis (tanning) and sexual stimulation via MC4R. Not FDA approved. Higher side effect burden than Melanotan I due to MC3R/MC4R activity.

Molecular Weight

1024.2 Da

Formula

C50H69N15O9

Common Dosing

0.25–1 mg SC 2–3x weekly

Reported Benefits

Tanning/melanogenesis

Preliminary 18 studies

Animal and small human studies confirm pigmentation; no Phase III human tanning trials.

Sexual stimulation

Moderate Evidence 14 studies

Phase II data for ED; PT-141 (derived from MT-II) subsequently went to FDA approval for HSDD.

Mechanism of Action

Non-selective melanocortin agonist; MC1R drives tanning/melanogenesis; MC4R drives sexual arousal and appetite suppression; MC3R modulates energy homeostasis.

Risk Profile Caveat

Melanotan II is not FDA approved and has a substantially higher side effect burden than its derivatives (Melanotan I for EPP, PT-141/Bremelanotide for HSDD). Nevi (moles) darkening under MT-II requires dermatological monitoring for melanoma risk. The unapproved status and risk profile place it in the high-risk category for unsupervised use.

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Regulatory Status

Research Only

Safety Profile

Side Effects

•Nausea (~50%)
•Facial flushing
•Spontaneous erections
•Appetite suppression
•Darkening of moles/nevi (monitoring required)
•Hypertension

Contraindications

•Melanoma history
•Cardiovascular disease
•Pregnancy

Drug Interactions

•Antihypertensives
•Vasoactive drugs

Primary Uses

TanningSexual arousalErectile functionAppetite suppression

Related Peptides

Melanotan I PT-141 GHK-Cu

Used For

›Sexual Health & Reproductive Function

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Disclaimer: This information is for educational and research purposes only. Not medical advice. Consult a qualified healthcare provider before using any compound.