Leuphasyl
low riskAlso: Pentapeptide-18 · Lipopeptide-18
Leuphasyl is a pentapeptide analog of enkephalin that modulates facial neuromuscular function through a mechanism distinct from argireline. It targets delta-opioid receptors on neurons rather than SNARE complex components.
Reported Benefits
Expression Line Reduction
Manufacturer-sponsored studies show wrinkle depth reduction.
Synergy with Argireline
Combination with argireline shows additive wrinkle reduction.
Mechanism of Action
Leuphasyl mimics the endogenous opioid enkephalin, binding to delta-opioid receptors on peripheral neurons. This reduces cAMP levels and calcium-dependent neurotransmitter release — a different mechanistic approach to reducing neuromuscular transmission than SNAP-complex inhibitors like argireline.
Key Clinical Studies
Lipotec study (2009)
manufacturer · Clinical evaluation
Leuphasyl reduces crow's feet wrinkle depth in combination protocols
Overview
Leuphasyl represents a different mechanistic approach to cosmetic peptide-based wrinkle reduction — using opioid receptor modulation rather than SNARE complex inhibition. The enkephalin-based mechanism is pharmacologically distinct from argireline/SNAP-8, providing rationale for combination use.
Enkephalin Mechanism
Enkephalins are endogenous opioid pentapeptides (Met-enkephalin and Leu-enkephalin) that modulate pain and neural signaling. Leuphasyl’s structural similarity to enkephalin allows it to activate peripheral delta-opioid receptors, reducing neurotransmitter release through a cAMP-dependent mechanism.
Evidence Quality
Like most cosmetic peptides beyond argireline and matrixyl, leuphasyl’s evidence base is largely manufacturer-sponsored with limited independent validation. The combination studies with argireline are mechanistically compelling but lack independent replication.
Market Position
Leuphasyl is primarily positioned as a complementary ingredient to argireline in anti-aging formulations rather than as a standalone active. The dual-mechanism rationale makes it appealing for formulators seeking comprehensive expression line reduction.
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Regulatory Status
Research OnlyCosmetic ingredient; INCI name Pentapeptide-18; no FDA drug approval
Safety Profile
Side Effects
- •Skin irritation (rare)
Contraindications
- •None established
Drug Interactions
- •None established
Primary Uses
Related Peptides
Used For
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