Cathelicidins
low riskAlso: Cathelicidin family · LL-37 precursor family · CAMP proteins
Reference entry for cathelicidins — the second major class of human antimicrobial peptides alongside defensins. LL-37 is the only human cathelicidin active form. Other mammals produce multiple cathelicidins. Important in skin barrier function, respiratory defense, and innate immune signaling.
Reported Benefits
Antimicrobial / immune defense
Well-characterized innate immunity role. Multiple clinical trials ongoing for LL-37 (the human cathelicidin).
Mechanism of Action
C-terminal amphipathic alpha-helical active domains disrupt bacterial and fungal membranes; also modulate TLR signaling, promote wound healing, and have antiviral properties.
LL-37 As the Exemplar
LL-37 is the only processed, active cathelicidin in humans. For clinical detail on cathelicidin pharmacology, see the LL-37 entry. This entry provides taxonomic and biological context for the broader family.
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Regulatory Status
Research OnlySafety Profile
Side Effects
- •Dose-dependent cytotoxicity
Contraindications
- •Autoimmune conditions (theoretical)
Primary Uses
Related Peptides
Used For
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