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Alpha-MSH

low risk

Also: α-Melanocyte Stimulating Hormone · ACTH(1-13) · Melanotropin

Moderate Evidence Research Only

Alpha-MSH is an endogenous melanocortin peptide from the pro-opiomelanocortin (POMC) precursor. Has broad anti-inflammatory properties, regulates skin pigmentation, suppresses appetite via MC4R, and provides neuroprotection. Precursor to Melanotan I and II pharmacology.

Molecular Weight
1664.9 Da
Formula
C76H100N18O19S
Common Dosing
Research only; not standardized for human use
Category
research
Last Reviewed
2025-01-15

Reported Benefits

Anti-inflammatory

Moderate Evidence 87 studies

Extensive evidence for peripheral and central anti-inflammatory effects; basis for melanocortin anti-inflammatory drug development.

Melanogenesis

Strong Evidence 120 studies

Foundational melanocyte biology. MC1R activation drives melanin synthesis — well-characterized.

Mechanism of Action

Endogenous agonist at MC1R (melanogenesis), MC3R (energy balance), MC4R (appetite suppression); activates anti-inflammatory pathways via NF-κB inhibition; reduces TNF-α, IL-6, IL-1β.

The Melanocortin System

Alpha-MSH is the endogenous reference point for the entire melanocortin drug class: Melanotan I (MC1R-selective), Melanotan II (non-selective), PT-141/Bremelanotide (MC3R/MC4R). Understanding α-MSH physiology clarifies why these drugs have their respective profiles.

Regulatory Status

Research Only

Safety Profile

Side Effects

  • •Not applicable as endogenous hormone

Contraindications

  • •N/A

Primary Uses

Anti-inflammatoryMelanogenesisAppetite suppressionNeuroprotection

Related Peptides

melanotan-imelanotan-iipt-141

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Disclaimer: This information is for educational and research purposes only. Not medical advice. Consult a qualified healthcare provider before using any compound.