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IGF-1 DES

high risk

Also: IGF-1 DES(1-3) · Truncated IGF-1 · Des-IGF-1

Preliminary Research Only

IGF-1 DES is a truncated form of IGF-1 lacking the first 3 amino acids of the N-terminus. Has approximately 10x greater potency than standard IGF-1 at the receptor but does not bind IGF binding proteins — limiting systemic distribution. Used for localized muscle hypertrophy by injection at target sites.

Molecular Weight
7000-7400 Da (approx)
Formula
Unknown (truncated IGF-1 analog)
Common Dosing
50–100 mcg per injection site, post-workout; injected directly into target muscle
Category
research
Last Reviewed
2025-01-15

Reported Benefits

Local muscle hypertrophy

Preliminary 8 studies

Animal and in vitro data show localized anabolic effects; human controlled data absent.

Mechanism of Action

Truncated IGF-1 lacking N-terminal tripeptide; does not bind IGFBPs → primarily local receptor activation; more potent receptor binding than intact IGF-1; activates local mTOR/satellite cell pathways.

Local vs. Systemic: The Distinction

Unlike IGF-1 LR3 (systemic distribution), IGF-1 DES’s lack of binding protein affinity means it acts primarily at the injection site. This is the basis for its localized hypertrophy claims. The evidence for this claimed specificity in humans is largely preclinical.

Regulatory Status

Research Only

Safety Profile

Side Effects

  • •Local tissue overgrowth
  • •Hypoglycemia (less than LR3)
  • •WADA-prohibited
  • •Injection site complications

Contraindications

  • •Active malignancy
  • •Cancer history

Drug Interactions

  • •Insulin

Primary Uses

Local muscle growthTissue-specific anabolicRecovery

Related Peptides

igf-1-lr3mgftb-500

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Disclaimer: This information is for educational and research purposes only. Not medical advice. Consult a qualified healthcare provider before using any compound.