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Alamandine

low risk

Also: Ala1-Ang(1-7) · Alamandine heptapeptide

Preliminary Research Only

Alamandine is a recently discovered heptapeptide member of the renin-angiotensin system, related to Angiotensin (1-7) but acting on MrgD receptors instead of Mas receptors. Shows cardiovascular and anti-fibrotic effects in animal models. Human data is very limited.

Molecular Weight
899.1 Da
Formula
C34H49N9O9
Common Dosing
Not standardized for humans; IV and SC in animal studies
Category
research
Last Reviewed
2025-01-15

Reported Benefits

Cardiovascular/anti-fibrotic

Preliminary 12 studies

Animal models show cardiac fibrosis reduction and blood pressure lowering via MrgD activation.

Mechanism of Action

Activates MrgD (Mas-related G protein-coupled receptor D); counter-regulatory to Angiotensin II; vasodilatory and anti-fibrotic effects in cardiac and renal tissue.

Novel RAS Member

Alamandine was only characterized in 2013. It represents a new branch of the renin-angiotensin system with therapeutic potential distinct from both Angiotensin (1-7) and classical ACE inhibitors. Human research is in early stages.

Regulatory Status

Research Only

Safety Profile

Side Effects

  • •Hypotension (potential)

Contraindications

  • •Severe hypotension
  • •Pregnancy

Primary Uses

Cardiovascular protectionAnti-fibroticAnti-hypertension

Related Peptides

angiotensin-1-7bpc-157

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Disclaimer: This information is for educational and research purposes only. Not medical advice. Consult a qualified healthcare provider before using any compound.